Next-Generation Lipid Nanoparticles

Engineering nanostructured materials using polyphenol-functionalized polymers

Chan-Jin Kim, Shiyao Li, Gyeongeun Heo, Zhaoran Wang, Yi Ju, Frank Caruso

2026-07-01

The assembly of nanostructured materials with tunable properties is of growing interest across fundamental research and industrial..

Sub-nm Pore Size Engineering in Metal–Phenolic Membranes

YZ Chen, QZ Zhong, JRT Chen, X Chen, Z Wang, JJ Richardson, Y Lv, T Liu, F Caruso

2026-03-25

Metal–organic membranes with tunable nanopores provide a versatile platform for energy-efficient, high-precision separations. Howe..

Polyphenol-Mediated Nucleic Acid Complexation Generates Biofunctional Nanoparticles

Meizhang Lu, Jingqu Chen, Zhixing Lin, Shiyao Li, Wanjun Xu, Hongjing Luo, Die Yang, Tianzheng Wang, Weining Sun, Frank Caruso

2026-01-01

Nucleic acids play central roles in heredity, protein synthesis, and the regulation of cellular activities, inspiring the developm..

Targeted Coacervates Enabled by Polyphenol–Peptide Networks for Therapeutic Delivery

L Jiang, Q Song, Z Lin, H Liu, J Chen, X Zhang, H Li, C Cortez-Jugo, J Zhou, L Liu, F Caruso, H Jiang

2026-01-01

Precise intracellular delivery remains a critical barrier to the efficacy of therapeutic biomolecules. Coacervates, with their hig..

Polyphenol-Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases.

Shiyao Li, Patrick Charchar, Haitao Yu, Zhixing Lin, Hamish G Brown, Wanjun Xu, Chan-Jin Kim, Irene Yarovsky, Yi Ju, Frank Caruso

2025-09-15

Lipids self-assemble into lipid nanoparticles (LNPs) with different crystalline mesophases, including lamellar and nonlamellar (e...